Combining use of Phillyrin and autophagy blocker alleviates laryngeal squamous cell carcinoma via AMPK/mTOR/p70S6K signaling
Identifieur interne : 000942 ( Main/Exploration ); précédent : 000941; suivant : 000943Combining use of Phillyrin and autophagy blocker alleviates laryngeal squamous cell carcinoma via AMPK/mTOR/p70S6K signaling
Auteurs : Da-Hua Wang [République populaire de Chine] ; Xi He [République populaire de Chine] ; Qing He [République populaire de Chine]Source :
- Bioscience Reports [ 0144-8463 ] ; 2019.
Abstract
Phillyrin (PHN), one of the major active constituents of
Url:
DOI: 10.1042/BSR20190459
PubMed: 31147451
PubMed Central: 6616054
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Combining use of Phillyrin and autophagy blocker alleviates laryngeal squamous cell carcinoma via AMPK/mTOR/p70S6K signaling</title><author><name sortKey="Wang, Da Hua" sort="Wang, Da Hua" uniqKey="Wang D" first="Da-Hua" last="Wang">Da-Hua Wang</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Otolaryngology, Xuzhou Municipal Hospital Affiliated with Xuzhou Medical University, Xuzhou 221002, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Otolaryngology, Xuzhou Municipal Hospital Affiliated with Xuzhou Medical University, Xuzhou 221002</wicri:regionArea><wicri:noRegion>Xuzhou 221002</wicri:noRegion></affiliation></author><author><name sortKey="He, Xi" sort="He, Xi" uniqKey="He X" first="Xi" last="He">Xi He</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Dermatology, Xuzhou Municipal Hospital Affiliated with Xuzhou Medical University, Xuzhou 221002, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Dermatology, Xuzhou Municipal Hospital Affiliated with Xuzhou Medical University, Xuzhou 221002</wicri:regionArea><wicri:noRegion>Xuzhou 221002</wicri:noRegion></affiliation></author><author><name sortKey="He, Qing" sort="He, Qing" uniqKey="He Q" first="Qing" last="He">Qing He</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Neurology, Xuzhou Municipal Hospital Affiliated with Xuzhou Medical University, Xuzhou 221002, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurology, Xuzhou Municipal Hospital Affiliated with Xuzhou Medical University, Xuzhou 221002</wicri:regionArea><wicri:noRegion>Xuzhou 221002</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31147451</idno><idno type="pmc">6616054</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616054</idno><idno type="RBID">PMC:6616054</idno><idno type="doi">10.1042/BSR20190459</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000435</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000435</idno><idno type="wicri:Area/Pmc/Curation">000435</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000435</idno><idno type="wicri:Area/Pmc/Checkpoint">000879</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000879</idno><idno type="wicri:Area/Ncbi/Merge">000660</idno><idno type="wicri:Area/Ncbi/Curation">000660</idno><idno type="wicri:Area/Ncbi/Checkpoint">000660</idno><idno type="wicri:doubleKey">0144-8463:2019:Wang D:combining:use:of</idno><idno type="wicri:Area/Main/Merge">000942</idno><idno type="wicri:Area/Main/Curation">000942</idno><idno type="wicri:Area/Main/Exploration">000942</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Combining use of Phillyrin and autophagy blocker alleviates laryngeal squamous cell carcinoma via AMPK/mTOR/p70S6K signaling</title><author><name sortKey="Wang, Da Hua" sort="Wang, Da Hua" uniqKey="Wang D" first="Da-Hua" last="Wang">Da-Hua Wang</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Otolaryngology, Xuzhou Municipal Hospital Affiliated with Xuzhou Medical University, Xuzhou 221002, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Otolaryngology, Xuzhou Municipal Hospital Affiliated with Xuzhou Medical University, Xuzhou 221002</wicri:regionArea><wicri:noRegion>Xuzhou 221002</wicri:noRegion></affiliation></author><author><name sortKey="He, Xi" sort="He, Xi" uniqKey="He X" first="Xi" last="He">Xi He</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Dermatology, Xuzhou Municipal Hospital Affiliated with Xuzhou Medical University, Xuzhou 221002, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Dermatology, Xuzhou Municipal Hospital Affiliated with Xuzhou Medical University, Xuzhou 221002</wicri:regionArea><wicri:noRegion>Xuzhou 221002</wicri:noRegion></affiliation></author><author><name sortKey="He, Qing" sort="He, Qing" uniqKey="He Q" first="Qing" last="He">Qing He</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Neurology, Xuzhou Municipal Hospital Affiliated with Xuzhou Medical University, Xuzhou 221002, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurology, Xuzhou Municipal Hospital Affiliated with Xuzhou Medical University, Xuzhou 221002</wicri:regionArea><wicri:noRegion>Xuzhou 221002</wicri:noRegion></affiliation></author></analytic><series><title level="j">Bioscience Reports</title><idno type="ISSN">0144-8463</idno><idno type="eISSN">1573-4935</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Phillyrin (PHN), one of the major active constituents of <italic>Forsythia suspensa</italic> and <italic>F. koreana</italic>, has been reported to produce antioxidant, antibacterial, anti-obesity and anti-inflammatory effects. However, no study has demonstrated the role of PHN in laryngeal squamous cell carcinoma (LSCC). We aimed to investigate the effects of PHN on the proliferation and apoptosis of HEp-2 cells. In the present study, PHN alone showed little effect on HEp-2 cell proliferation and apoptosis. Subsequent tests showed that PHN could largely enhance the level of autophagy on HEp-2 cells. Combining use of PHN and autophagy blockers including 3-methyladenine (3-MA) and chloroquine (CQ) significantly inhibited HEp-2 cell proliferation in a dose- and time-dependent manner and induced apoptosis after 24 h in a dose-dependent manner. Additionally, we found that the possible underlying molecular mechanism of PHN-induced autophagy might be through the AMPK/mTOR/p70S6K signaling pathway. Taken together, our study indicates that combining use of PHN and autophagy blockers may serve as a novel strategy in LSCC treatment.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Fanjul Fernandez, M" uniqKey="Fanjul Fernandez M">M. Fanjul-Fernandez</name></author><author><name sortKey="Quesada, V" uniqKey="Quesada V">V. Quesada</name></author><author><name sortKey="Cabanillas, R" uniqKey="Cabanillas R">R. Cabanillas</name></author><author><name sortKey="Cadinanos, J" uniqKey="Cadinanos J">J. Cadinanos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Vito, R" uniqKey="De Vito R">R. De Vito</name></author><author><name sortKey="Lee, Y C A" uniqKey="Lee Y">Y.C.A. Lee</name></author><author><name sortKey="Parpinel, M" uniqKey="Parpinel M">M. Parpinel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Y H" uniqKey="Wu Y">Y.H. 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